Following Tuesday’s matches, at least four teams qualified for the FA quarter-finals.
Phil Foden scored twice for Manchester City as the Premier League champions defeated Bristol City 3-0.
Kevin De Bruyne completed the score with a stunning 25-yard strike.
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Second-tier Blackburn Rovers ousted Leicester City winning 2-1.
Tyrhys Dolan and Sammie Szmodics scored first, followed by Kelechi Iheanacho.
Fulham entered the sixth round for the first time in 13 years courtesy to goals by João Palhinha and David Solomon, which secured them a 2-0 win over Leeds United.
Brighton and Hove Albion needed Evan Ferguson’s first-half goal to beat second-tier Stoke City 1-0.